Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester

Base Information

Chemical Name:Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester
CAS No.:259185-50-7
Molecular Formula:C₅₃H₆₈ClN₂O₁₀P
Molecular Weight:959.557
Hs Code.:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester

Synonyms:Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester

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Chemical Property of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester

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Technology Process of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester

There total 4 articles about Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 36653-82-4,124-29-8
1-Hexadecanol

: 85393-37-9
5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

: 259185-50-7
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester

Guidance literature:: With MSNT; In pyridine; at 20 ℃; for 0.5h;
DOI:10.1080/07328319908044627

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 259185-50-7
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2,4-triazole; Et₃N; 1-methylimidazole / tetrahydrofuran / 0.17 h

2: H₂O / tetrahydrofuran

3: 100 percent / MSNT / pyridine / 0.5 h / 20 °C

With 1,2,4-Triazole; 1-methyl-1H-imidazole; MSNT; water; triethylamine; In tetrahydrofuran; pyridine; 1: Condensation / 2: Hydrolysis / 3: Condensation;
DOI:10.1080/07328319908044627

Reference yield:

: 103309-63-3
Phosphorochloridic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

: 259185-50-7
Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester hexadecyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O / tetrahydrofuran

2: 100 percent / MSNT / pyridine / 0.5 h / 20 °C

With MSNT; water; In tetrahydrofuran; pyridine; 1: Hydrolysis / 2: Condensation;
DOI:10.1080/07328319908044627