4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine

Base Information

• Chemical Name: 4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine
• CAS No.: 1557968-81-6
• Molecular Formula: C₂₀H₁₆Cl₂N₆
• Molecular Weight: 411.293
• Mol file: 1557968-81-6.mol

Synonyms:4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine

Chemical Property of 4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine

There total 3 articles about 4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(E)-1-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-3-(2,4-dichlorophenyl)prop-2-en-1-one (1403580-83-5) + guanidine hydrochloride (50-01-1) → 4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine (1557968-81-6)

Guidance literature:

With sodium hydroxide; In water; for 0.666667h; Reflux;

DOI:10.1016/j.cclet.2013.12.017

Reference yield:

(azidomethyl)cyclohexane (81917-06-8) → 4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine (1557968-81-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / ethanol / Reflux

2: sodium hydroxide / water / 20 °C

3: sodium hydroxide / ethanol / 0.67 h / Reflux

With potassium carbonate; sodium hydroxide; In ethanol; water;

DOI:10.1002/jccs.201500010

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine (1557968-81-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / ethanol / Reflux

2: sodium hydroxide / water / 20 °C

3: sodium hydroxide / ethanol / 0.67 h / Reflux

With potassium carbonate; sodium hydroxide; In ethanol; water;

DOI:10.1002/jccs.201500010

upstream raw materials:

(E)-1-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-3-(2,4-dichlorophenyl)prop-2-en-1-one

guanidine hydrochloride

(azidomethyl)cyclohexane

acetylacetone