(2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone

Base Information

Chemical Name:(2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone
CAS No.:93292-78-5
Molecular Formula:C₃₆H₅₄O₈
Molecular Weight:614.82
Hs Code.:

Synonyms:(2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone

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Chemical Property of (2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone

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Technology Process of (2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone

There total 6 articles about (2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 88289-25-2
2-methoxy-3-tetrahydropyranyloxy-1-bromobenzene

: 65423-55-4
(3R,4R)-2-Methylene-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone

: 93292-78-5
(2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone

Guidance literature:: With copper(l) iodide; tributylphosphine; tert.-butyl lithium; In diethyl ether; at -78 ℃;
DOI:10.1016/0040-4039(84)80039-8

Reference yield:

: 17269-81-7
2-bromo-6-(2-propenyl)phenol

: 93292-78-5
(2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / KOt-Bu / 2-methyl-propan-2-ol

2: basic alumina (Woelm, akt I) / hexane; ethyl acetate / by eluting through a column

3: O₃

4: m-chloroperbenzoic acid / CH₂Cl₂

6: 69 percent / t-butyllithium, copper iodide, tri-n-butylphosphine / diethyl ether / -78 °C

With aluminum oxide; copper(l) iodide; tributylphosphine; potassium tert-butylate; tert.-butyl lithium; ozone; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; hexane; dichloromethane; ethyl acetate; tert-butyl alcohol;
DOI:10.1016/0040-4039(84)80039-8

Reference yield:

: 88275-87-0
3-bromo-2-methyloxybenzaldehyde

: 93292-78-5
(2R,3R,4R)-2-[2-Methoxy-3-(tetrahydro-pyran-2-yloxy)-benzyl]-4-(tetrahydro-pyran-2-yloxy)-3-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-cyclopentanone

Guidance literature:: Multi-step reaction with 3 steps

1: m-chloroperbenzoic acid / CH₂Cl₂

3: 69 percent / t-butyllithium, copper iodide, tri-n-butylphosphine / diethyl ether / -78 °C

With copper(l) iodide; tributylphosphine; tert.-butyl lithium; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;
DOI:10.1016/0040-4039(84)80039-8