C₁₃H₁₂BrNO

Base Information

• Chemical Name: C₁₃H₁₂BrNO
• CAS No.: 1206975-97-4
• Molecular Formula: C₁₃H₁₂BrNO
• Molecular Weight: 278.148
• Mol file: 1206975-97-4.mol

Synonyms:C₁₃H₁₂BrNO

Chemical Property of C₁₃H₁₂BrNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₃H₁₂BrNO

There total 1 articles about C₁₃H₁₂BrNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

benzyl bromide (100-39-0) + (2-bromopyrid-3-yl)methanol (131747-54-1) → C13H12BrNO (1206975-97-4)

Guidance literature:

(2-bromopyrid-3-yl)methanol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; for 3h;

DOI:10.1055/s-0033-1340179

Reference yield:

chloro-trimethyl-silane (75-77-4) + C13H12BrNO (1206975-97-4) → C16H21NOSi

Guidance literature:

C₁₃H₁₂BrNO; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h;

chloro-trimethyl-silane; In diethyl ether; hexane; at 20 ℃;

DOI:10.1055/s-0033-1340179

Reference yield:

C13H12BrNO (1206975-97-4) → C17H17NO3 (1609627-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C

1.2: 20 °C

2.1: 1,2-dichloro-ethane / 100 °C

3.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 °C / Molecular sieve

3.2: 2 h / 20 °C / Molecular sieve

With n-butyllithium; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In diethyl ether; hexane; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1055/s-0033-1340179

upstream raw materials:

benzyl bromide

(2-bromopyrid-3-yl)methanol

Downstream raw materials:

C₁₇H₁₇NO₃

C₁₈H₂₀F₃NO₅S