3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile

Base Information

Chemical Name:3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile
CAS No.:88295-39-0
Molecular Formula:C₃₃H₃₁Cl₃N₄O₆
Molecular Weight:685.991
Hs Code.:

Synonyms:3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile

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Chemical Property of 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile

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Technology Process of 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile

There total 14 articles about 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 115-20-8
1,1,1-trichloroethanol

: 88287-72-3
3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylic acid

: 88295-39-0
3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In toluene; for 1.5h; Heating;
DOI:10.1021/jo00177a028

Reference yield:

: 31083-47-3
Methyl 3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-5-carbamoylpyrazole-4-carboxylate

: 88295-39-0
3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / pyridine, trifluoroacetic anhydride / dioxane; tetrahydrofuran / 1.) 0-5 deg C, 45 min, 2.) room temp., 18 h

2: 93 percent / NaOH / methanol; H₂O / 18 h / Heating

3: 76 percent / diphenyl phosphoryl azide, triethylamine / toluene / 1.5 h / Heating

With pyridine; sodium hydroxide; diphenyl phosphoryl azide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;
DOI:10.1021/jo00177a028

Reference yield:

: 88287-69-8
Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate

: 88295-39-0
3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / NaOH / methanol; H₂O / 18 h / Heating

2: 76 percent / diphenyl phosphoryl azide, triethylamine / toluene / 1.5 h / Heating

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; In methanol; water; toluene;
DOI:10.1021/jo00177a028