5-{[(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid

Base Information

Chemical Name:5-{[(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid
CAS No.:918950-51-3
Molecular Formula:C₂₇H₂₈NO₆P
Molecular Weight:493.496
Hs Code.:

5-{[(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid

Synonyms:5-{[(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-{[(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid

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Technology Process of 5-{[(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid

There total 2 articles about 5-{[(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 918950-48-8
5-hydroxyphosphinoyl-pentanoic acid

: 84418-43-9
9-fluorenylmethyl carbamate

: 100-52-7
benzaldehyde

: 918950-51-3
5-{[(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid

Guidance literature:: With acetic acid; acetyl chloride; at 20 ℃; for 4h;
DOI:10.1021/jo061535z

Reference yield:

: 591-80-0
pent-4-enoic acid

: 918950-51-3
5-{[(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NH₄H₂PO₂; triethylborane / methanol; hexane / 2 h / 20 °C

2: 87 percent / acetyl chloride; acetic acid / 4 h / 20 °C

With ammonium hypophosphorous acid; triethyl borane; acetic acid; acetyl chloride; In methanol; hexane;
DOI:10.1021/jo061535z