tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate
CAS No.:1359840-96-2
Molecular Formula:C₂₅H₃₃ClN₂O₂
Molecular Weight:429.002
Hs Code.:

Synonyms:tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate

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Chemical Property of tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate

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Technology Process of tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate

There total 7 articles about tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1359840-95-1
tert-butyl {2-[1-(4-chlorophenyl)cyclobutyl]-2-(3-formylphenyl)ethyl}carbamate

: 74-89-5
methylamine

: 1359840-96-2
tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate

Guidance literature:: tert-butyl {2-[1-(4-chlorophenyl)cyclobutyl]-2-(3-formylphenyl)ethyl}carbamate; methylamine; In dichloromethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

: 106079-12-3
1-(4-chlorophenyl)-cyclobutanecarboxaldehyde

: 1359840-96-2
tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tert-butyl alcohol; tetrahydrofuran / 20 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.42 h / -30 °C

4.1: zinc; acetic acid / tetrahydrofuran / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 60 °C

6.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

7.1: dichloromethane / 1 h / 20 °C

7.2: 20 °C

With potassium tert-butylate; isopropylmagnesium chloride; diisobutylaluminium hydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; zinc; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1359840-90-6
1-chloro-4-{1-[(E)-2-nitroethenyl]cyclobutyl}benzene

: 1359840-96-2
tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.42 h / -30 °C

2.1: zinc; acetic acid / tetrahydrofuran / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 60 °C

4.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

5.1: dichloromethane / 1 h / 20 °C

5.2: 20 °C

With isopropylmagnesium chloride; diisobutylaluminium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;