3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

Base Information

Chemical Name:3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole
CAS No.:1192117-37-5
Molecular Formula:C₁₇H₁₂ClF₃N₂O
Molecular Weight:352.743
Hs Code.:

Synonyms:3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

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Chemical Property of 3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

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Technology Process of 3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

There total 9 articles about 3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1192118-94-7
5-chloro-3-(4-methoxy-phenyl)-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

: 74-88-4
methyl iodide

: 1192117-37-5
3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

: 1448006-00-5
C₁₇H₁₂ClF₃N₂O

Guidance literature:: 5-chloro-3-(4-methoxy-phenyl)-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole; With potassium carbonate;

methyl iodide;
DOI:10.1055/s-0033-1338433

Reference yield:

: 1192118-94-7
5-chloro-3-(4-methoxy-phenyl)-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

: 74-88-4
methyl iodide

: 1192117-37-5
3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 0 ℃; for 18h;

Reference yield:

: 918418-99-2
ethyl 2,4,6-trifluorophenylglyoxylate

: 1192117-37-5
3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine

2: potassium hydroxide

3: aluminum (III) chloride

4: potassium carbonate

5: 10 wt% Pd(OH)2 on carbon / cyclohexene

6: potassium carbonate

With aluminum (III) chloride; 10 wt% Pd(OH)2 on carbon; potassium carbonate; triphenylphosphine; potassium hydroxide; In cyclohexene; 1: |Corey-Fuchs Alkyne Synthesis / 3: |Friedel-Crafts Acylation;
DOI:10.1055/s-0033-1338433