3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole

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Chemical Name:3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole
CAS No.:1192117-64-8
Molecular Formula:C₁₈H₁₅ClF₂N₂O₂
Molecular Weight:364.779
Hs Code.:

Synonyms:3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole

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Chemical Property of 3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole

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Technology Process of 3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole

There total 9 articles about 3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192117-37-5
3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,4,6-trifluoro-phenyl)-1H-pyrazole

: 124-41-4
sodium methylate

: 1192117-64-8
3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole

Guidance literature:: regioselective reaction;
DOI:10.1055/s-0033-1338433

Reference yield:

: 2367-76-2
2,4,6-trifluorobromobenzene

: 1192117-64-8
3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 8 steps

1: isopropylmagnesium chloride

2: triphenylphosphine

3: potassium hydroxide

4: aluminum (III) chloride

5: potassium carbonate

6: 10 wt% Pd(OH)2 on carbon / cyclohexene

7: potassium carbonate

With aluminum (III) chloride; 10 wt% Pd(OH)2 on carbon; isopropylmagnesium chloride; potassium carbonate; triphenylphosphine; potassium hydroxide; In cyclohexene; 2: |Corey-Fuchs Alkyne Synthesis / 4: |Friedel-Crafts Acylation;
DOI:10.1055/s-0033-1338433

Reference yield:

: 918418-99-2
ethyl 2,4,6-trifluorophenylglyoxylate

: 1192117-64-8
3-chloro-5-(4-methoxy-phenyl)-1-methyl-4-(2,6-difluoro-4-methoxy-phenyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1: triphenylphosphine

2: potassium hydroxide

3: aluminum (III) chloride

4: potassium carbonate

5: 10 wt% Pd(OH)2 on carbon / cyclohexene

6: potassium carbonate

With aluminum (III) chloride; 10 wt% Pd(OH)2 on carbon; potassium carbonate; triphenylphosphine; potassium hydroxide; In cyclohexene; 1: |Corey-Fuchs Alkyne Synthesis / 3: |Friedel-Crafts Acylation;
DOI:10.1055/s-0033-1338433