3-(3-Hydroxy-propylamino)-propan-1-ol

Base Information

• Chemical Name: 3-(3-Hydroxy-propylamino)-propan-1-ol
• CAS No.: 14002-33-6
• Molecular Formula: C6H15NO2
• Molecular Weight: 133.191
• Hs Code.: 2922199090
• European Community (EC) Number: 269-796-7,837-644-4
• DSSTox Substance ID: DTXSID40930695
• Nikkaji Number: J27.964A
• Wikidata: Q72446059
• Mol file: 14002-33-6.mol

Synonyms:14002-33-6;3,3'-Azanediylbis(propan-1-ol);3-(3-Hydroxy-propylamino)-propan-1-ol;3-(3-hydroxypropylamino)propan-1-ol;3,3'-azanediyldipropan-1-ol;68333-85-7;Propanol, iminobis-;bis(3-hydroxypropyl)amine;EINECS 269-796-7;EINECS 286-662-3;SELENIUMBROMIDE;di-(3-hydroxypropyl) amine;SCHEMBL48646;1-Propanol,3,3'-iminobis-;DTXSID40930695;3,3'-Azanediyldi(propan-1-ol);CXMYWOCYTPKBPP-UHFFFAOYSA-N;AC-515;MFCD00046013;1-Propanol,3,3'-(methylimino)bis-;AKOS009030989;3-(3-hydroxypropylamino)-propan-1-ol;3-[(3-hydroxypropyl)amino]propan-1-ol;AMY202100020;AS-19774;CS-0186731;FT-0601642;EN300-141457;O10901;A807612;Z104684334

Chemical Property of 3-(3-Hydroxy-propylamino)-propan-1-ol

Chemical Property:

• Boiling Point: 268.858 °C at 760 mmHg
• PKA: 14.73±0.10(Predicted)
• Flash Point: 129.676 °C
• PSA: 52.49000
• Density: 1.014 g/cm³
• LogP: -0.26830
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 133.110278721
• Heavy Atom Count: 9
• Complexity: 44.3

Purity/Quality:

99% ^*data from raw suppliers

3,3'-azanediyldipropan-1-ol AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: UVCB
• Canonical SMILES: C(CNCCCO)CO

Technology Process of 3-(3-Hydroxy-propylamino)-propan-1-ol

There total 13 articles about 3-(3-Hydroxy-propylamino)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,3‘-(benzylazanediyl)bis(propan-1-ol) (5279-23-2) → bis-(3-hydroxypropyl)amine (14002-33-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 2280 Torr;

DOI:10.1039/p19960001553

Reference yield: 88.0%

methyl 2-(3-hydroxypropylcarbamoyl)ethanoate → bis-(3-hydroxypropyl)amine (14002-33-6)

Guidance literature:

With lithium aluminium tetrahydride; In 1,4-dioxane; for 24h; Heating;

Reference yield: 85.0%

propan-1-ol-3-amine (156-87-6) + 1-chloro-3-hydroxypropane (627-30-5) → bis-(3-hydroxypropyl)amine (14002-33-6) + tripropanolamine (14002-34-7)

Guidance literature:

With sodium carbonate; In ethanol; for 24h; Heating;

DOI:10.1039/b101118i

upstream raw materials:

toluene-4-sulfonamide

1,3-dibromo-propane

methylimine-N,N-dipropionate methyl ester

3,3'-imino-di-propionic acid diethyl ester

Downstream raw materials:

2,10-dioxa-6-aza-1-phosphabicyclo<4.4.0>decane

12,17-dimethyl-5-tosyl-1,5,9,12,17-penta-azabicyclo-<7.5.5>nonadecane

{2-[9-Methanesulfonyl-5,13-bis-(toluene-4-sulfonyl)-1,5,9,13-tetraaza-cyclohexadec-1-yl]-ethyl}-dimethyl-amine

3,3'-iminobis-1-propanol dinitrate nitrate

Refernces

• 1、 -. "TRIAZACYCLODODECANSULFONAMIDE ("TCD")-BASED PROTEIN SECRETION INHIBITORS". Paragraph 00190. . Retrieved 2019/10/04.
• 2、 -. "COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING SIRNA ACTIVITY". Page/Page column 47. . Retrieved 2013/02/27.