ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate

Base Information

Chemical Name:ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate
CAS No.:1318787-30-2
Molecular Formula:C₂₃H₂₄FN₃O₄
Molecular Weight:425.46
Hs Code.:

Synonyms:ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate

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Chemical Property of ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate

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Technology Process of ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate

There total 7 articles about ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318790-02-1
1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl chloride

: 1318789-62-6
ethyl (S)-3-amino-3-(2-methyl-phenyl)-propionate hydrochloride

: 1318787-30-2
ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate

Guidance literature:: With triethylamine; In 2-methyltetrahydrofuran; Cooling with ice;

Reference yield:

: 2924-15-4
(2-fluorophenyl)hydrazine hydrochloride

: 1318787-30-2
ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / water / 2.42 h

2.1: thionyl chloride / 4 h / 20 °C

3.1: potassium carbonate / water; 4-methyl-2-pentanone / 2.5 h / 20 °C

4.1: sodium hydroxide; water / 4-methyl-2-pentanone / 16 h / 20 °C

4.2: pH 3

5.1: oxalyl dichloride / N,N-dimethyl-formamide / 2-methyltetrahydrofuran / 16 h / 0 - 20 °C

6.1: triethylamine / 2-methyltetrahydrofuran / Cooling with ice

With thionyl chloride; oxalyl dichloride; sulfuric acid; water; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; water; 4-methyl-2-pentanone;

Reference yield:

: 1239726-11-4
1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid

: 1318787-30-2
ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 2-methyltetrahydrofuran / 16 h / 0 - 20 °C

2: triethylamine / 2-methyltetrahydrofuran / Cooling with ice

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran;