Ethyl (alphaR)-alpha-(benzoylamino)benzeneacetate

Base Information

Chemical Name:Ethyl (alphaR)-alpha-(benzoylamino)benzeneacetate
CAS No.:10419-68-8
Molecular Formula:C₁₇H₁₇NO₃
Molecular Weight:283.327
Hs Code.:
DSSTox Substance ID:DTXSID101269056
Nikkaji Number:J61.861F

Synonyms:(?)-Ethyl alpha-Phenylhippurate;DTXSID101269056;Ethyl (alphaR)-alpha-(benzoylamino)benzeneacetate;10419-68-8

Suppliers and Price of Ethyl (alphaR)-alpha-(benzoylamino)benzeneacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl (alphaR)-alpha-(benzoylamino)benzeneacetate

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:283.12084340
Heavy Atom Count:21
Complexity:344

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2
Isomeric SMILES:CCOC(=O)[C@@H](C1=CC=CC=C1)NC(=O)C2=CC=CC=C2

Technology Process of Ethyl (alphaR)-alpha-(benzoylamino)benzeneacetate

There total 4 articles about Ethyl (alphaR)-alpha-(benzoylamino)benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 591-50-4
iodobenzene

: 201230-82-2
carbon monoxide

: 17609-48-2
(R)-2-phenylglycine ethyl ester hydrochloride

: 10419-68-8
(R)-ethyl-2-benzamido-2-phenylacetate

Guidance literature:: With di-tert-butylphosphinoferrocene tetrafluoroborate; palladium diacetate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 120 ℃; for 4h; under 2585.81 Torr; Biotage Endeavor system;
DOI:10.1016/j.tetlet.2009.08.065

Reference yield: 69.0%

: 108-86-1,52753-63-6
bromobenzene

: 201230-82-2
carbon monoxide

: 17609-48-2
(R)-2-phenylglycine ethyl ester hydrochloride

: 10419-68-8
(R)-ethyl-2-benzamido-2-phenylacetate

Guidance literature:: With di-tert-butylphosphinoferrocene tetrafluoroborate; palladium diacetate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 120 ℃; for 9h; under 10343.2 Torr; Biotage Endeavor system;
DOI:10.1016/j.tetlet.2009.08.065

Reference yield:

: 64-17-5
ethanol

: 29670-63-1
N-benzoyl-2-phenylglycine

: 10419-68-8
(R)-ethyl-2-benzamido-2-phenylacetate

: 7554-21-4
(S)-ethyl 2-benzamido-2-phenylacetate

Guidance literature:: With Bis-HQN-SQA; In dichloromethane; at -20 ℃; for 24h; optical yield given as %ee; enantioselective reaction;
DOI:10.1039/b917882a