chloromethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate

Base Information

• Chemical Name: chloromethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate
• CAS No.: 1301763-78-9
• Molecular Formula: C₃₃H₅₄ClN₃O₈
• Molecular Weight: 656.26
• Mol file: 1301763-78-9.mol

Synonyms:chloromethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate

Chemical Property of chloromethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of chloromethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate

There total 2 articles about chloromethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dichloromethane (75-09-2) + carbonochloridic acid, chloromethyl ester (22128-62-7) + (2S,4S,5S,7S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide hemifumarate → chloromethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate (1301763-78-9)

Guidance literature:

carbonochloridic acid, chloromethyl ester; (2S,4S,5S,7S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide hemifumarate; With sodium carbonate; In water; at 20 ℃;

dichloromethane; In water; at 20 ℃;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + carbonochloridic acid, chloromethyl ester (22128-62-7) + (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide (173334-57-1) → chloromethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate (1301763-78-9)

Guidance literature:

formaldehyd; (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide; In tetrahydrofuran; water; Cooling with ice;

carbonochloridic acid, chloromethyl ester; With triethylamine; In tetrahydrofuran; for 0.5h; Cooling with ice;

Reference yield:

chloromethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate (1301763-78-9) → iodomethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate (1301763-90-5)

Guidance literature:

With sodium iodide; In acetonitrile; at 75 ℃; for 1.33333h;

upstream raw materials:

dichloromethane

carbonochloridic acid, chloromethyl ester

formaldehyd

(2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide

Downstream raw materials:

pyridin-3-ylmethyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate

{(4S,5S)-5-[(2S)-2-(3-amino-2,2-dimethyl-3-oxopropylaminocarbonyl)-3-methylbutyl]-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidin-3-yl-carbonyloxy}methyl morpholine-4-carboxylate

1-(isobutyryloxy)methyl (4S,5S)-5-[(S)-2-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-3-methylbutyl]-4-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}oxazolidine-3-carboxylate

({[(1-methylpiperidin-4-yl)oxy]carbonyl}oxy)methyl (4S,5S)-5-((2S)-2-{[(3-amino-2,2-dimethyl-3-oxopropyl)amino]carbonyl}-3-methylbutyl)-4-{(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl}-1,3-oxazolidine-3-carboxylate trifluoroacetate