(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoic acid

Base Information

Chemical Name:(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoic acid
CAS No.:1151451-88-5
Molecular Formula:C₂₇H₃₈N₄O₉S
Molecular Weight:594.686
Hs Code.:

Synonyms:(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoic acid

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Chemical Property of (R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoic acid

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Technology Process of (R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoic acid

There total 4 articles about (R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1378928-93-8
(R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate

: 1151451-88-5
(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoic acid

Guidance literature:: With hydrogenchloride; In dichloromethane; at 0 ℃;
DOI:10.1021/jm300199g

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 1151451-88-5
(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 18 h / 60 °C

2: hydrogenchloride / dichloromethane / 0 °C

With pyridine; hydrogenchloride; In dichloromethane;
DOI:10.1021/jm300199g

Reference yield:

: 1151451-77-2
4-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)benzaldehyde

: 1151451-88-5
(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 42 h / 20 °C / Inert atmosphere; Molecular sieve

2: pyridine / 18 h / 60 °C

3: hydrogenchloride / dichloromethane / 0 °C

With pyridine; hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane;
DOI:10.1021/jm300199g