Dimethyl thiophene-2,3-dicarboxylate

Base Information

• Chemical Name: Dimethyl thiophene-2,3-dicarboxylate
• CAS No.: 14300-68-6
• Molecular Formula: C8H8 O4 S
• Molecular Weight: 200.215
• Hs Code.: 2934999090
• Mol file: 14300-68-6.mol

Synonyms:2,3-Thiophenedicarboxylicacid, dimethyl ester (7CI,8CI,9CI); Dimethyl 2,3-thiophenedicarboxylate

Chemical Property of Dimethyl thiophene-2,3-dicarboxylate

Chemical Property:

• Vapor Pressure: 0.0191mmHg at 25°C
• Melting Point: 32-33 °C
• Boiling Point: 252.6°C at 760 mmHg
• Flash Point: 106.6°C
• PSA: 80.84000
• Density: 1.294g/cm³
• LogP: 1.32130
• Storage Temp.: 2-8°C

Purity/Quality:

97%, ^*data from raw suppliers

Dimethylthiophene-2,3-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl thiophene-2,3-dicarboxylate

There total 9 articles about Dimethyl thiophene-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanol (67-56-1) + thiophene-2,3-dicarboxylic acid (1451-95-2) → 2,3-Thiophendicarbonsaeure-dimethylester (14300-68-6)

Guidance literature:

With thionyl chloride; Heating;

DOI:10.1055/s-1996-4372

Reference yield: 16.0%

2,3-dihydrothiophene (1120-59-8) + dimethyl acetylenedicarboxylate (762-42-5) → 2,3-Thiophendicarbonsaeure-dimethylester (14300-68-6) + ethene (74-85-1)

Guidance literature:

In benzene; at 80 ℃;

Reference yield: 6.0%

dimethyl acetylenedicarboxylate (762-42-5) + trans-2,3-bis(trimethylsilyl)thiirane 1-oxide (114693-75-3) → 2,3-Thiophendicarbonsaeure-dimethylester (14300-68-6) + 2,3-dicarbomethoxy-4-(trimethylsilyl)thiophene (114693-77-5)

Guidance literature:

In toluene; at 130 ℃; for 7.5h;

DOI:10.1021/ja00222a037

upstream raw materials:

diazomethane

thiophene-2,3-dicarboxylic acid

methanol

2,3-dihydrothiophene

Downstream raw materials:

5,6-dihydro-thieno[2,3-d]pyridazine-4,7-dione

7-chloro-4-(4-chlorophenylamino)thieno[2,3-d]pyridazine

4-[({4-[(4-chlorophenyl)amino]-thieno[2,3-d]pyridazin-7-yl}oxy)methyl]-2-pyridinecarboxamide

N-(1,3-benzothiazol-6-yl)-N-{4-[(4-bromophenyl)amino]thieno[2,3-d]pyridazin-7-yl}amine

Refernces

• 1、 -. "COMPOUNDS FOR TREATING PULMONARY HYPERTENSION". Page/Page column 56. . Retrieved 2008/06/13.
• 2、 Murray, William M.,Semple, J. Edward. "Facile access to novel 1,4-dihydroxynaphthalene-2,3-dicarboximides and heterofused analogs". . p. 1180 - 1182. Retrieved 2007/10/03.