4-FLUOROBENZOIC ANHYDRIDE

Base Information

• Chemical Name: 4-FLUOROBENZOIC ANHYDRIDE
• CAS No.: 25569-77-1
• Molecular Formula: C14H8 F2 O3
• Molecular Weight: 262.213
• Hs Code.: 2916399090
• Mol file: 25569-77-1.mol

Synonyms:Benzoicacid, 4-fluoro-, anhydride (9CI); Benzoic acid, p-fluoro-, anhydride (8CI);4-Fluorobenzoic anhydride; p-Fluorobenzoic anhydride

Chemical Property of 4-FLUOROBENZOIC ANHYDRIDE

Chemical Property:

• Vapor Pressure: 4.61E-06mmHg at 25°C
• Melting Point: 107-108℃
• Boiling Point: 382.8°C at 760 mmHg
• Flash Point: 178.9°C
• PSA: 43.37000
• Density: 1.343
• LogP: 2.96200
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Moisture Sensitive
• Water Solubility.: Sparingly soluble in water.(0.26 g/L) (25°C),

Purity/Quality:

99% ^*data from raw suppliers

4-Fluorobenzoicanhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Technology Process of 4-FLUOROBENZOIC ANHYDRIDE

There total 8 articles about 4-FLUOROBENZOIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-fluoro-1-iodobenzene (352-34-1) + carbon monoxide (201230-82-2) → 4-fluorobenzoic anhydride (25569-77-1)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; water; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 20 - 115 ℃; for 6h; under 760.051 Torr; Inert atmosphere; Autoclave;

DOI:10.1039/c2cc16611a

Reference yield: 98.0%

4-Fluorobenzoic acid (456-22-4) + 4-fluorobenzoyl chloride (403-43-0) → 4-fluorobenzoic anhydride (25569-77-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Wavelength; Inert atmosphere;

DOI:10.1039/c9nj01984g

Reference yield: 95.0%

4-Fluorobenzoic acid (456-22-4) → 4-fluorobenzoic anhydride (25569-77-1)

Guidance literature:

With potassium carbonate; p-toluenesulfonyl chloride; In acetonitrile; at 20 ℃; for 2.5h;

DOI:10.2174/1570178614666170329153759

upstream raw materials:

4-Fluorobenzoic acid

4-fluoro-1-iodobenzene

carbon monoxide

4-fluorobenzoyl chloride

Downstream raw materials:

3-phenylpropionic acid 3-phenylpropyl ester

3-phenyl-1-propyl p-fluorobenzoate

2,6-Difluor-fluorenon

4-fluorobenzophenone

Refernces

• 1、 Gaspa, Silvia,Raposo, Inês,Pereira, Leonor,Mulas, Gabriele,Ricci, Pier Carlo,Porcheddu, Andrea,De Luca, Lidia. "Visible light-induced transformation of aldehydes to esters, carboxylic anhydrides and amides". supporting information. p. 10711 - 10715. Retrieved 2019/07/15.
• 2、 Eskandari, Parvin,Kazemi, Foad. "An investigation on practical synthesis of carboxylic acid derivatives using p-toluenesulfonyl chloride". . p. 431 - 439. Retrieved 2017/07/24.