6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide

Base Information

Chemical Name:6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide
CAS No.:1622243-02-0
Molecular Formula:C₁₄H₁₄FN₃O₂
Molecular Weight:275.282
Hs Code.:

Synonyms:6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide

Chemical Property:

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Technology Process of 6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide

There total 6 articles about 6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1214342-46-7
6-amino-3-(3-fluorophenyl)picolinic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1622243-02-0
6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 5327-33-3
2-acetylamino-6-methylpyridine

: 1622243-02-0
6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium permanganate / water / 3 h / 75 °C

1.2: 12 h / Reflux

2.1: bromine; sodium carbonate / acetic acid / 5 h / 20 °C

3.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,3-dioxane / 2 h / 90 °C

4.1: water; lithium hydroxide monohydrate / ethanol / 2 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium permanganate; lithium hydroxide monohydrate; water; bromine; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,3-dioxane; ethanol; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 36052-26-3
methyl 6-aminopyridine-2-carboxylate

: 1622243-02-0
6-amino-3-(3-fluorophenyl)-N-methoxy-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; sodium carbonate / acetic acid / 5 h / 20 °C

2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,3-dioxane / 2 h / 90 °C

3: water; lithium hydroxide monohydrate / ethanol / 2 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide monohydrate; water; bromine; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,3-dioxane; ethanol; water; acetic acid; N,N-dimethyl-formamide;