4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide

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Chemical Name:4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide
CAS No.:862465-69-8
Molecular Formula:C₃₃H₅₉NO₈Si
Molecular Weight:625.919
Hs Code.:

4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide

Synonyms:4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide

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Chemical Property of 4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide

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Technology Process of 4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide

There total 12 articles about 4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 862465-86-9
(4S)-3-[4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-2-methylbutanoyl]-4-benzyl-1,3-oxazolidin-2-one

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 862465-69-8
4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide

Guidance literature:: With trimethylaluminum; In tetrahydrofuran; at -10 - 0 ℃; for 10h;
DOI:10.1021/ol051225n

Reference yield:

: 862465-63-2
tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

: 862465-69-8
4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 89 percent / Raney Nickel; H₂ / ethanol / 3 h / 20 °C / 760 Torr

2.1: 90 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

3.1: 87 percent / isopropylmagnesium chloride / tetrahydrofuran / -30 - 0 °C

4.1: 93 percent / MgBr₂*Et₂O; n-tributyltin chloride / CH₂Cl₂ / 5 h / 20 °C

5.1: 89 percent / tetrahydrofuran / 2 h / 0 °C

6.1: EtBOMe; NaBH₄ / tetrahydrofuran; methanol / 9 h / -78 °C

6.2: H₂O₂ / methanol; tetrahydrofuran; H₂O / -78 - 20 °C

7.1: 3.80 g / PPTs / CH₂Cl₂ / 1 h / 20 °C

8.1: 86 percent / pyridine; O₃; Sudan III / Ph₃P / CH₂Cl₂; methanol / -78 - 20 °C

9.1: n-Bu₂BOTf; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 0 °C

9.2: 93 percent / CH₂Cl₂ / 2 h / -78 - 0 °C

10.1: 73 percent / AlMe₃ / tetrahydrofuran / 10 h / -10 - 0 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; oil scarlet; di-n-butylboryl trifluoromethanesulfonate; tributyltin chloride; hydrogen; trimethylaluminum; isopropylmagnesium chloride; pyridinium p-toluenesulfonate; nickel; ozone; triethylamine; magnesium bromide; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/ol051225n

Reference yield:

: 862465-64-3
2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

: 862465-69-8
4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 93 percent / MgBr₂*Et₂O; n-tributyltin chloride / CH₂Cl₂ / 5 h / 20 °C

2.1: 89 percent / tetrahydrofuran / 2 h / 0 °C

3.1: EtBOMe; NaBH₄ / tetrahydrofuran; methanol / 9 h / -78 °C

3.2: H₂O₂ / methanol; tetrahydrofuran; H₂O / -78 - 20 °C

4.1: 3.80 g / PPTs / CH₂Cl₂ / 1 h / 20 °C

5.1: 86 percent / pyridine; O₃; Sudan III / Ph₃P / CH₂Cl₂; methanol / -78 - 20 °C

6.1: n-Bu₂BOTf; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 0 °C

6.2: 93 percent / CH₂Cl₂ / 2 h / -78 - 0 °C

7.1: 73 percent / AlMe₃ / tetrahydrofuran / 10 h / -10 - 0 °C

With pyridine; sodium tetrahydroborate; oil scarlet; di-n-butylboryl trifluoromethanesulfonate; tributyltin chloride; trimethylaluminum; pyridinium p-toluenesulfonate; ozone; triethylamine; magnesium bromide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol051225n