13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid

Base Information

Chemical Name:13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid
CAS No.:877290-96-5
Molecular Formula:C₃₀H₃₂N₂O₅
Molecular Weight:500.594
Hs Code.:

Synonyms:13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid

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Chemical Property of 13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid

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Technology Process of 13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid

There total 7 articles about 13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 877270-31-0
5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-6-(4-morpholinylcarbonyl)methyl ester

: 877290-96-5
13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 90 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/jm4016894

Reference yield:

: 877269-51-7
methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

: 877290-96-5
13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / N,N-dimethyl-formamide / 4 h / 50 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 22 °C

3: sodium hydroxide / methanol; tetrahydrofuran / 0.25 h / 90 °C / Microwave irradiation

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm4016894

Reference yield:

: 877287-47-3
methyl 3-cyclohexyl-2-(2-formylphenyl)-1H-indole-6-carboxylate

: 877290-96-5
13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

2: lithium hydroxide / N,N-dimethyl-formamide / 4 h / 50 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 22 °C

4: sodium hydroxide / methanol; tetrahydrofuran / 0.25 h / 90 °C / Microwave irradiation

With caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm4016894