methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

Base Information

• Chemical Name: methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate
• CAS No.: 877269-51-7
• Molecular Formula: C₂₇H₂₇NO₄
• Molecular Weight: 429.516

Synonyms:methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

Chemical Property of methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

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Technology Process of methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

There total 11 articles about methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 11-cyclohexyl-6-hydroxy-6H-isoindolo[2,1-a]indole-3-carboxylate (877267-79-3) + trimethyl phosphonoacetate (5927-18-4) → methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate (877269-51-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

Reference yield: 96.0%

methyl 3-cyclohexyl-2-(2-formylphenyl)-1H-indole-6-carboxylate (877287-47-3) + trimethyl 2-phosphonoacrylate (55168-74-6) → methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate (877269-51-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.12.085

Reference yield: 96.0%

methyl 11-cyclohexyl-6-hydroxy-6H-isoindolo[2,1-a]indole-3-carboxylate (877267-79-3) + trimethyl 2-phosphonoacrylate (55168-74-6) → methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate (877269-51-7)

Guidance literature:

With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

methyl 11-cyclohexyl-6-hydroxy-6H-isoindolo[2,1-a]indole-3-carboxylate

trimethyl 2-phosphonoacrylate

methyl 3-cyclohexyl-1-(2-(methoxycarbonyl)allyl)-2-(2-vinylphenyl)-1H-indole-6-carboxylate

trimethyl phosphonoacetate

Downstream raw materials:

methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid

13-cyclohexyl-N-(dimethylsulfamoyl)-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

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