methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

Base Information

Chemical Name:methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate
CAS No.:877271-71-1
Molecular Formula:C₂₆H₂₅NO₄
Molecular Weight:415.489
Hs Code.:

Synonyms:methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

Suppliers and Price of methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

There total 11 articles about methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 877269-51-7
methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

: 877271-71-1
methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

Guidance literature:: methyl 13-cyclohexyl-6-(methoxycarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxylate; With methanol; tetra(n-butyl)ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate; at 20 ℃;

Reference yield:

: 877271-76-6
methyl 13-cyclohexyl-6-(benzyloxycarbonyl)-5H-indolo[2,1-a][2]benzazepine-10-carboxylate

: 877271-71-1
methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; at 22 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: 1670-82-2,261352-47-0
Indole-6-carboxylic acid

: 877271-71-1
methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether / 1 h / -15 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 12 h / 10 - 20 °C

3: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.67 h / 0 - 20 °C

4: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 3 h / 85 °C

5: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

6: lithium hydroxide / N,N-dimethyl-formamide / 4 h / 50 °C

With triethylsilane; lithium hydroxide; pyridinium hydrobromide perbromide; sodium carbonate; caesium carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;