Technology Process of 5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-6-(4-morpholinylcarbonyl)methyl ester
There total 12 articles about 5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-6-(4-morpholinylcarbonyl)methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 22 ℃;
for 0.333333h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrakis(triphenylphosphine) palladium(0); lithium chloride; sodium carbonate / ethanol; toluene / 3 h / 80 °C / Inert atmosphere
2: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
3: lithium hydroxide / N,N-dimethyl-formamide / 4 h / 50 °C
4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 22 °C
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide;
In
ethanol; N,N-dimethyl-formamide; toluene;
1: |Suzuki-Miyaura Coupling / 2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm4016894
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylsilane; trifluoroacetic acid / dichloromethane / 12 h / 10 - 20 °C
2: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 h / 0 - 20 °C
3: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 3 h / 85 °C
4: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C
5: lithium hydroxide / N,N-dimethyl-formamide / 4 h / 50 °C
6: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 22 °C
With
triethylsilane; lithium hydroxide; pyridinium hydrobromide perbromide; sodium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;
