13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

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Chemical Name:13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide
CAS No.:877290-89-6
Molecular Formula:C₃₂H₃₈N₄O₆S
Molecular Weight:606.743
Hs Code.:

Synonyms:13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

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Chemical Property of 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

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Technology Process of 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

There total 9 articles about 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 3984-14-3
N,N-dimethylsulfamide

: C₃₀H₃₁ClN₂O₄

: 877290-89-6
13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 40 ℃;
DOI:10.1021/jm4016894

Reference yield:

: 877290-96-5
13-cyclohexyl-6-(morpholin-4-ylcarbonyl)-7H-indolo[2,1-a]-[2]benzazepine-10-carboxylic acid

: 877290-89-6
13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; dmap / N,N-dimethyl-formamide / 40 °C

With dmap; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm4016894

Reference yield:

: 877271-71-1
methyl 13-cyclohexyl-6-(carboxy)-5H-indolo[2,1-a][2]-benzazepine-10-carboxylate

: 877290-89-6
13-cyclohexyl-N-[(dimethylamino)sulfonyl]-3-methoxy-6-(4-morpholinylcarbonyl)-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 22 °C

2: sodium hydroxide / methanol; tetrahydrofuran / 0.25 h / 90 °C / Microwave irradiation

3: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; dmap / N,N-dimethyl-formamide / 40 °C

With dmap; oxalyl dichloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm4016894