2-chlorobenzyl methyl sulphide

Base Information

• Chemical Name: 2-chlorobenzyl methyl sulphide
• CAS No.: 57984-15-3
• Molecular Formula: C₈H₉ClS
• Molecular Weight: 172.678
• Mol file: 57984-15-3.mol

Synonyms:2-chlorobenzyl methyl sulphide

Chemical Property of 2-chlorobenzyl methyl sulphide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chlorobenzyl methyl sulphide

There total 6 articles about 2-chlorobenzyl methyl sulphide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methanethiosulfonic acid S-methyl ester (2949-92-0,31761-75-8) + 1-chloro-2-(chloromethyl)benzene (611-19-8) → 2-chlorobenzyl methyl sulphide (57984-15-3)

Guidance literature:

1-chloro-2-(chloromethyl)benzene; With magnesium; lithium chloride; zinc(II) chloride; In tetrahydrofuran; at 25 ℃; for 0.75h; Inert atmosphere;

methanethiosulfonic acid S-methyl ester; In tetrahydrofuran; at 25 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b812396a

Reference yield:

chloro-methylsulfanyl-methane (2373-51-5) + chlorobenzene (108-90-7) → (4-chlorobenzyl)(methyl)sulfane (5925-82-6) + 2-chlorobenzyl methyl sulphide (57984-15-3)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 0 ℃; for 0.5h; Yield given. Yields of byproduct given;

DOI:10.1055/s-1994-25458

Reference yield:

methylthiomethyl p-tolyl sulfone (59662-65-6) + chlorobenzene (108-90-7) → (4-chlorobenzyl)(methyl)sulfane (5925-82-6) + 2-chlorobenzyl methyl sulphide (57984-15-3)

Guidance literature:

aluminium trichloride; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) CH₂Cl₂, room temp., 2.) CH₂Cl₂, 0 gradC, 1 h;

DOI:10.1016/S0040-4039(00)82029-8

upstream raw materials:

chloro-methylsulfanyl-methane

chlorobenzene

methylthiomethyl p-tolyl sulfone

trimethylsulphonium iodide

Downstream raw materials:

(2-chloro-benzyl)-methyl sulfone

Refernces

• 1、 -. "Azetidine derivatives, their preparation and medicaments containing them". . . Retrieved 2008/06/13.
• 2、 Torisawa, Yasuhiro,Satoh, Atsushi,Ikegami, Shiro. "NOVEL AND EFFECTIVE METHODS FOR α-THIOALKYLATION OF AROMATIC COMPOUNDS". . p. 1729 - 1732. Retrieved 2007/10/02.