4'-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,3,4]oxadiazol-2-ylthio)methyl)biphenyl-2-carbonitrile

Base Information

Chemical Name:4'-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,3,4]oxadiazol-2-ylthio)methyl)biphenyl-2-carbonitrile
CAS No.:1374671-65-4
Molecular Formula:C₂₄H₁₇N₃O₃S
Molecular Weight:427.483
Hs Code.:

Synonyms:4'-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,3,4]oxadiazol-2-ylthio)methyl)biphenyl-2-carbonitrile

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Chemical Property of 4'-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,3,4]oxadiazol-2-ylthio)methyl)biphenyl-2-carbonitrile

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Technology Process of 4'-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,3,4]oxadiazol-2-ylthio)methyl)biphenyl-2-carbonitrile

There total 6 articles about 4'-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,3,4]oxadiazol-2-ylthio)methyl)biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 928710-56-9
5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2-thiol

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 1374671-65-4
4'-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,3,4]oxadiazol-2-ylthio)methyl)biphenyl-2-carbonitrile

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm300309a

Reference yield:

: 98953-13-0
2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid hydrazide

: 1374671-65-4
4'-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,3,4]oxadiazol-2-ylthio)methyl)biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / Reflux; Inert atmosphere

2: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300309a

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1374671-65-4
4'-((5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,3,4]oxadiazol-2-ylthio)methyl)biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 40 h / 80 °C / Inert atmosphere

3: sodium hydroxide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); sodium carbonate; sodium hydroxide; In tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling;
DOI:10.1021/jm300309a