ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

Base Information

• Chemical Name: ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate
• CAS No.: 119487-58-0
• Molecular Formula: C₂₇H₂₅N₃O₅
• Molecular Weight: 471.513

Synonyms:ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

Chemical Property of ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

Chemical Property:

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Technology Process of ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

There total 2 articles about ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate (108895-98-3) + ethyl bromoacetate (105-36-2) → ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate (119487-58-0)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 2 h, 2.) DMF, from 0 deg C to RT, 1 h;

DOI:10.1021/jm00078a018

Reference yield:

→ ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate (119487-58-0)

Guidance literature:

Reference yield: 100.0%

formic acid (64-18-6) + ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate (119487-58-0) → ethyl 3(R,S)-amino-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate formate salt

Guidance literature:

palladium on activated charcoal; In methanol; for 1.5h;

DOI:10.1021/jm00078a018

upstream raw materials:

benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

ethyl bromoacetate

Downstream raw materials:

1(Carboxymethyl)-1,3-Dihydro-5-phenyl-3(R,S)-[(benzyloxycarbonyl)-amino]2H-1,4-benzodiazepin-2-one

ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate

[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid

3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid

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