[2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate

Base Information

Chemical Name:[2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate
CAS No.:334708-46-2
Molecular Formula:C₂₀H₂₅NO₅
Molecular Weight:359.422
Hs Code.:

Synonyms:[2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate

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Chemical Property of [2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate

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Technology Process of [2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate

There total 3 articles about [2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 67-56-1
methanol

: (2R,3S)-3-(3,4-Dimethoxy-phenyl)-3-(4-methoxy-phenylamino)-2-methyl-propionic acid

: 334708-46-2
[2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate

Guidance literature:: for 6h; Heating;
DOI:10.1021/ol0155384

Reference yield:

: 130632-09-6
(E)-1-(3,4-dimethoxyphenyl)-N-(4-methoxyphenyl)methanimine

: 334708-46-2
[2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA; LiCl / tetrahydrofuran / -78 - 20 °C

1.2: 77 percent / tetrahydrofuran / 5 h / 0 °C

2.1: aq. H₂SO₄ / dioxane / 6 h / Heating

3.1: 78 percent / 6 h / Heating

With sulfuric acid; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; 1.2: Mannich reaction;
DOI:10.1021/ol0155384

Reference yield:

: 334708-41-7
[2R,3S,1'S,2'S]-(+)-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-N,2-dimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)propanamide

: 334708-46-2
[2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. H₂SO₄ / dioxane / 6 h / Heating

2: 78 percent / 6 h / Heating

With sulfuric acid; In 1,4-dioxane;
DOI:10.1021/ol0155384