(3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:(3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester
CAS No.:214354-03-7
Molecular Formula:C₃₂H₄₁N₃O₈
Molecular Weight:595.693
Hs Code.:

Synonyms:(3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester

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Chemical Property of (3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester

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Technology Process of (3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester

There total 1 articles about (3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214354-05-9
(S)-4-Benzyl-3-((S)-4-benzyloxy-5-bromo-pentanoyl)-oxazolidin-2-one

: C₃₂H₄₁N₃O₈

: 214354-03-7
(3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester

Guidance literature:: Yield given. Multistep reaction;
DOI:10.1016/S0040-4039(98)01533-0

Reference yield: 93.0%

: 67-56-1
methanol

: 214354-03-7
(3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester

: 214354-11-7
(3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

Guidance literature:: With sodium methylate; In dichloromethane; at -30 ℃; for 0.25h;
DOI:10.1016/S0040-4039(98)01533-0

Reference yield:

: 214354-03-7
(3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester

: 400019-84-3
(3S,5S)-5-Acetoxy-1-(2,4-dinitro-phenyl)-hexahydro-pyridazine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / NaOMe / CH₂Cl₂ / 0.25 h / -30 °C

2: 94 percent / hydrogen / Pd(OH)2 / methanol / 3 h / 760 Torr

3: pyridine / Ambient temperature

4: CH₂Cl₂ / 2 h / Heating

5: 85 percent / sat. aq. NaHCO₃ / CH₂Cl₂ / Ambient temperature

With pyridine; hydrogen; sodium methylate; sodium hydrogencarbonate; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)01533-0