(3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

Base Information

Chemical Name:(3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester
CAS No.:214354-11-7
Molecular Formula:C₂₃H₃₄N₂O₇
Molecular Weight:450.532
Hs Code.:

Synonyms:(3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

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Chemical Property of (3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

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Technology Process of (3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

There total 1 articles about (3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 67-56-1
methanol

: 214354-03-7
(3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester

: 214354-11-7
(3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

Guidance literature:: With sodium methylate; In dichloromethane; at -30 ℃; for 0.25h;
DOI:10.1016/S0040-4039(98)01533-0

Reference yield:

: 214354-11-7
(3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

: 31321-66-1
1-(2,4-dinitro-phenyl)-5-hydroxy-hexahydro-pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / hydrogen / Pd(OH)2 / methanol / 3 h / 760 Torr

2: pyridine / Ambient temperature

3: CH₂Cl₂ / 2 h / Heating

4: 85 percent / sat. aq. NaHCO₃ / CH₂Cl₂ / Ambient temperature

5: 72 percent / LiOH / tetrahydrofuran; H₂O / 1.17 h / 0 °C

With pyridine; lithium hydroxide; hydrogen; sodium hydrogencarbonate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(98)01533-0

Reference yield:

: 214354-11-7
(3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester

: 400019-84-3
(3S,5S)-5-Acetoxy-1-(2,4-dinitro-phenyl)-hexahydro-pyridazine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / hydrogen / Pd(OH)2 / methanol / 3 h / 760 Torr

2: pyridine / Ambient temperature

3: CH₂Cl₂ / 2 h / Heating

4: 85 percent / sat. aq. NaHCO₃ / CH₂Cl₂ / Ambient temperature

With pyridine; hydrogen; sodium hydrogencarbonate; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)01533-0