N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE

Base Information

• Chemical Name: N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE
• CAS No.: 898825-89-3
• Molecular Formula: C6H8N2O2S
• Molecular Weight: 172.208
• Hs Code.: 2934100090
• Mol file: 898825-89-3.mol

Synonyms:Thiazole-5-carboxylicacid N-methoxy-N-methylamide;

Chemical Property of N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE

Chemical Property:

• Vapor Pressure: 0.000173mmHg at 25°C
• Melting Point: 54-56 °C
• Refractive Index: 1.553
• Boiling Point: 329.8 °C at 760 mmHg
• PKA: 0.70±0.10(Predicted)
• Flash Point: 153.3 °C
• PSA: 70.67000
• Density: 1.287 g/cm³
• LogP: 0.77650
• Storage Temp.: Keep Cold

Purity/Quality:

97% ^*data from raw suppliers

N-Methoxy-N-methylthiazole-5-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE

There total 2 articles about N-METHOXY-N-METHYL 5-THIAZOLECARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

thiazole-5-carboxylic acid (14527-41-4) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methyl-thiazole-5-carboxamide (898825-89-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/acsmedchemlett.0c00443

Reference yield: 65.0%

thiazole-5-carboxylic acid (14527-41-4) + N,0-dimethylhydroxylamine (1117-97-1) → N-methoxy-N-methyl-thiazole-5-carboxamide (898825-89-3)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 90.0%

N-methoxy-N-methyl-thiazole-5-carboxamide (898825-89-3) + methylmagnesium bromide (75-16-1) → 1-(thiazol-5-yl) ethan-1-one (91516-28-8)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -10 - 20 ℃; for 16.16h; Inert atmosphere;

upstream raw materials:

thiazole-5-carboxylic acid

N,0-dimethylhydroxylamine

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

1-(thiazol-5-yl) ethan-1-one