5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE

Base Information

• Chemical Name: 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE
• CAS No.: 913836-17-6
• Molecular Formula: C7H6BrNO3
• Molecular Weight: 232.034
• Hs Code.: 2933399090
• Mol file: 913836-17-6.mol

Synonyms:4-pyridinecarboxylic acid, 5-bromo-2-hydroxy-, methyl ester;

Chemical Property of 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE

Chemical Property:

• Boiling Point: 400.9 °C at 760 mmHg
• PKA: 8.96±0.10(Predicted)
• Flash Point: 196.3 °C
• PSA: 59.42000
• Density: 1.716 g/cm³
• LogP: 1.33630
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl5-Bromo-2-hydroxyisonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE

There total 6 articles about 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 2-amino-5-bromo-pyridine-4-carboxylate (882499-87-8) → methyl 5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate (913836-17-6)

Guidance literature:

With sulfuric acid; water; sodium nitrite; at 0 - 20 ℃; for 0.5h;

Reference yield:

methanol (67-56-1) + C6H4BrNO3 (913836-16-5) → methyl 5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate (913836-17-6)

Guidance literature:

With sulfuric acid;

Reference yield:

5-bromo-2-methoxy-pyridine-4-carbaldehyde (936011-17-5) → methyl 5-bromo-2-oxo-1,2-dihydropyridine-4-carboxylate (913836-17-6)

Guidance literature:

Multi-step reaction with 4 steps

1: dihydrogen peroxide; formic acid / 0 - 4 °C

2: sulfuric acid

3: hydrogen bromide / water

4: sulfuric acid

With formic acid; sulfuric acid; hydrogen bromide; dihydrogen peroxide; In water;

upstream raw materials:

methanol

C₆H₄BrNO₃

5-bromo-2-methoxy-pyridine-4-carbaldehyde

5-bromo-2-methoxypyridine-4-carboxylic acid

Downstream raw materials:

C₁₉H₁₀F₄N₂O₂

C₂₆H₁₈F₄N₂O₃

C₁₉H₁₁F₄NO₄

C₁₉H₁₂F₄N₂O₃

Refernces

• 1、 -. "ANTI-FIBROTIC PYRIDINONES". Paragraph 0717. . Retrieved 2015/11/02.