methyl 2,4-diphenylfuran-3-carboxylate

Base Information

• Chemical Name: methyl 2,4-diphenylfuran-3-carboxylate
• CAS No.: 1221575-74-1
• Molecular Formula: C₁₈H₁₄O₃
• Molecular Weight: 278.307
• Mol file: 1221575-74-1.mol

Synonyms:methyl 2,4-diphenylfuran-3-carboxylate

Chemical Property of methyl 2,4-diphenylfuran-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2,4-diphenylfuran-3-carboxylate

There total 3 articles about methyl 2,4-diphenylfuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 2,4-diphenyl-but-3-yne-1,2-diol (58294-83-0) → methyl 2,4-diphenylfuran-3-carboxylate (1221575-74-1)

Guidance literature:

With potassium iodide; palladium(II) iodide; at 100 ℃; for 2h; under 30402 Torr; Autoclave;

DOI:10.1021/jo301628n

Reference yield: 56.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 2,4-diphenyl-but-3-yne-1,2-diol (58294-83-0) → methyl 2,4-diphenylfuran-3-carboxylate (1221575-74-1)

Guidance literature:

With oxygen; potassium iodide; palladium dichloride; at 100 ℃; for 2h; under 30402 Torr; Autoclave;

DOI:10.1016/j.tetlet.2010.01.054

Reference yield:

1-phenyl-2-hydroxyethanone (582-24-1) + phenylacetylene (536-74-3) → methyl 2,4-diphenylfuran-3-carboxylate (1221575-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; lithium bromide / hexane; tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere

1.2: 2 h / -40 °C / Inert atmosphere

2.1: palladium(II) iodide; potassium iodide / 2 h / 100 °C / 30402 Torr / Autoclave

With n-butyllithium; potassium iodide; lithium bromide; palladium(II) iodide; In tetrahydrofuran; hexane;

DOI:10.1021/jo301628n

upstream raw materials:

methanol

carbon monoxide

2,4-diphenyl-but-3-yne-1,2-diol

1-phenyl-2-hydroxyethanone