diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate

Base Information

Chemical Name:diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate
CAS No.:1268526-97-1
Molecular Formula:C₂₈H₃₂N₃O₄P
Molecular Weight:505.554
Hs Code.:

Synonyms:diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate

Suppliers and Price of diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate

There total 10 articles about diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1660-94-2
Tetraethyl methylenediphosphonate

: 1186635-72-2
5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde

: 1268526-97-1
diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate

Guidance literature:: Tetraethyl methylenediphosphonate; With sodium hydride; In tetrahydrofuran; at 0 ℃;

5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridine-8-carbaldehyde; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
DOI:10.1021/acs.jmedchem.6b00489

Reference yield:

: 85331-33-5
2-Cyano-3,5-dichloropyridine

: 1268526-97-1
diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / butan-1-ol; water / 100 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2.5 h / 20 °C

6: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

With potassium phosphate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1186637-69-3
3-chloro-5-((4-methoxy-2-methylphenyl)ethynyl)picolinonitrile

: 1268526-97-1
diethyl (E)-2-(5-amino-2-(4-methoxy-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)vinylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / butan-1-ol; water / 100 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2.5 h / 20 °C

5: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

With potassium phosphate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; butan-1-ol;