ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate
CAS No.:1402141-66-5
Molecular Formula:C₂₃H₂₃ClINO₂
Molecular Weight:507.799
Hs Code.:

Synonyms:ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate

There total 1 articles about ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 107-10-8,42939-71-9
propylamine

: 1384513-05-6
ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

: 1402141-66-5
ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate

Guidance literature:: In methanol; at 20 ℃; for 6h;
DOI:10.1021/jm3010306

Reference yield:

: 1402141-66-5
ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate

: 1402141-70-1
5-(4-chlorophenyl)-2-methyl-4-(3-(4-(4-nitrophenyl)piperazin-1-yl)phenyl)-1-propyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 80 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane; ethanol; water / 20 h / Reflux; Inert atmosphere

2.2: Inert atmosphere

With copper(l) iodide; potassium carbonate; L-proline; sodium hydroxide; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; 1.1: |Ullmann Condensation;
DOI:10.1021/jm3010306

Reference yield:

: 1402141-66-5
ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylate

: 1402141-72-3
5-(4-chlorophenyl)-4-(3-(4-(4-(4-fluoro-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl)-phenyl)-2-methyl-1-propyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 8 h / 80 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane; ethanol; water / 20 h / Reflux; Inert atmosphere

2.2: Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / methanol / 20 °C / Inert atmosphere

4.1: pyridine; aniline / 0 - 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; aniline; L-proline; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 1.1: |Ullmann Condensation;
DOI:10.1021/jm3010306