3,8-bis(tert-butoxycarbonylamino)-6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methylphenanthridiniumiodide

Base Information

Chemical Name:3,8-bis(tert-butoxycarbonylamino)-6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methylphenanthridiniumiodide
CAS No.:1613454-82-2
Molecular Formula:C₃₅H₄₀FN₆O₅*I
Molecular Weight:770.643
Hs Code.:

Synonyms:3,8-bis(tert-butoxycarbonylamino)-6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methylphenanthridiniumiodide

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Chemical Property of 3,8-bis(tert-butoxycarbonylamino)-6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methylphenanthridiniumiodide

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Technology Process of 3,8-bis(tert-butoxycarbonylamino)-6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methylphenanthridiniumiodide

There total 10 articles about 3,8-bis(tert-butoxycarbonylamino)-6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methylphenanthridiniumiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 894792-94-0
1-azido-2-fluoroethane

: 1314081-06-5
3,8-bis(tert-butoxycarbonylamino)-5-methyl-6-(4-( prop-2-ynyloxy)phenyl)phenanthridinium iodide

: 1613454-82-2
3,8-bis(tert-butoxycarbonylamino)-6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methylphenanthridiniumiodide

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In N,N-dimethyl-formamide; at 23 ℃; Inert atmosphere;
DOI:10.1039/c3ob42379d

Reference yield:

: 51787-75-8
4,4'-dinitro-2-biphenylamine

: 1613454-82-2
3,8-bis(tert-butoxycarbonylamino)-6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methylphenanthridiniumiodide

Guidance literature:: Multi-step reaction with 9 steps

1: 24 h / Inert atmosphere; Reflux

2: ammonium formate; 20% palladium hydroxide-activated charcoal / methanol; ethyl acetate / 3 h / Inert atmosphere; Reflux

3: triethylamine / dichloromethane / 23 °C / Inert atmosphere

4: trichlorophosphate / 6 h / Inert atmosphere; Reflux

5: hydrogen bromide / 72 h / Inert atmosphere; Reflux

6: tert-butyl alcohol / 48 h / 23 °C / Inert atmosphere

7: potassium carbonate / toluene; acetone / 8 h / Inert atmosphere; Reflux

8: tetrahydrofuran / 120 h / Inert atmosphere; Reflux

9: sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide / 23 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; 20% palladium hydroxide-activated charcoal; hydrogen bromide; ammonium formate; potassium carbonate; sodium L-ascorbate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;
DOI:10.1039/c3ob42379d

Reference yield:

: 1314081-04-3
di-tert-butyl [6-(4-hydroxyphenyl)phenanthridine-3,8-diyl]dicarbamate

: 1613454-82-2
3,8-bis(tert-butoxycarbonylamino)-6-(4-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-5-methylphenanthridiniumiodide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / toluene; acetone / 8 h / Inert atmosphere; Reflux

2: tetrahydrofuran / 120 h / Inert atmosphere; Reflux

3: sodium L-ascorbate; copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide / 23 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1039/c3ob42379d