3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylic acid

Base Information

Chemical Name:3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylic acid
CAS No.:1332706-79-2
Molecular Formula:C₂₄H₁₈F₂N₂O₃
Molecular Weight:420.415
Hs Code.:

Synonyms:3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylic acid

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Chemical Property of 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylic acid

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Technology Process of 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylic acid

There total 10 articles about 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332707-16-0
ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

: 1332706-79-2
3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylic acid

Guidance literature:: ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate; With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In water;

Reference yield:

: 87121-89-9
ethyl 3-oxocyclobutanecarboxylate

: 1332706-79-2
3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 80 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 120 °C

4: cyclohexa-1,4-diene; ethanol / palladium(II) hydroxide / ethyl acetate / 2 h / 130 °C / microwave irradiation

5: potassium trimethylsilonate / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; ethanol; cyclohexa-1,4-diene; potassium trimethylsilonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 17205-02-6
ethyl trans-3-hydroxycyclobutanecarboxylate

: 1332706-79-2
3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 80 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 120 °C

3: cyclohexa-1,4-diene; ethanol / palladium(II) hydroxide / ethyl acetate / 2 h / 130 °C / microwave irradiation

4: potassium trimethylsilonate / tetrahydrofuran / 20 °C

With ethanol; cyclohexa-1,4-diene; potassium trimethylsilonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;