ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

Base Information

Chemical Name:ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate
CAS No.:1332707-16-0
Molecular Formula:C₂₆H₂₂F₂N₂O₃
Molecular Weight:448.469
Hs Code.:

Synonyms:ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

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Chemical Property of ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

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Technology Process of ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

There total 10 articles about ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332707-15-9
ethyl 3-{[5-(biphenyl-4-yl)-1-(biphenyl-4-ylmethyl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

: 1332707-16-0
ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

Guidance literature:: With ethanol; cyclohexa-1,4-diene; palladium(II) hydroxide; In ethyl acetate; at 130 ℃; for 2h; microwave irradiation;

Reference yield:

: 87121-89-9
ethyl 3-oxocyclobutanecarboxylate

: 1332707-16-0
ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 80 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 120 °C

4: cyclohexa-1,4-diene; ethanol / palladium(II) hydroxide / ethyl acetate / 2 h / 130 °C / microwave irradiation

With sodium tetrahydroborate; ethanol; cyclohexa-1,4-diene; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 17205-02-6
ethyl trans-3-hydroxycyclobutanecarboxylate

: 1332707-16-0
ethyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 80 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 120 °C

3: cyclohexa-1,4-diene; ethanol / palladium(II) hydroxide / ethyl acetate / 2 h / 130 °C / microwave irradiation

With ethanol; cyclohexa-1,4-diene; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide; In ethyl acetate; N,N-dimethyl-formamide;