1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanol

Base Information

Chemical Name:1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanol
CAS No.:1312018-07-7
Molecular Formula:C₂₆H₃₂N₂O₅S
Molecular Weight:484.616
Hs Code.:

Synonyms:1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanol

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Chemical Property of 1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanol

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Technology Process of 1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanol

There total 11 articles about 1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1312018-06-6
1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine

: 5623-81-4
2-cyclopentylacetaldehyde

: 1312018-07-7
1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanol

Guidance literature:: 1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

2-cyclopentylacetaldehyde; In tetrahydrofuran; at -78 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 271-63-6
7-Azaindole

: 1312018-07-7
1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine; formic acid / palladium 10% on activated carbon / 120 h / 0 - 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 3 h / 0 °C

3.1: bromine; pyridine / dichloromethane / 2 h / 0 °C

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h

5.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

5.2: 12.25 h / 0 - 25 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 20 - 80 °C

7.1: 1,4-bis(9-O-dihydroquinidine)phthalazine; methanesulfonamide / water; tert-butyl alcohol / 12 h / 0 °C

7.2: 0.5 h / 25 °C

8.1: toluene-4-sulfonic acid / dichloromethane / 12 h / 25 °C

9.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

9.2: 1 h / -78 °C

With pyridine; formic acid; methanesulfonamide; tetrabutylammomium bromide; bromine; sodium hydride; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 1-(tert-butyl-dimethyl-silanyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

: 1312018-07-7
1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine; pyridine / dichloromethane / 2 h / 0 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h

3.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

3.2: 12.25 h / 0 - 25 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 20 - 80 °C

5.1: 1,4-bis(9-O-dihydroquinidine)phthalazine; methanesulfonamide / water; tert-butyl alcohol / 12 h / 0 °C

5.2: 0.5 h / 25 °C

6.1: toluene-4-sulfonic acid / dichloromethane / 12 h / 25 °C

7.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

7.2: 1 h / -78 °C

With pyridine; methanesulfonamide; tetrabutylammomium bromide; bromine; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;