5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Base Information

Chemical Name:5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide
CAS No.:1454666-24-0
Molecular Formula:C₁₈H₁₄BrF₃N₄O₂S₂
Molecular Weight:519.366
Hs Code.:

Synonyms:5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

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Chemical Property of 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

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Technology Process of 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

There total 5 articles about 5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7552-07-0
1,3,4-thiadiazol-5-amine

: 1454667-12-9
5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1454666-24-0
5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: 1,3,4-thiadiazol-5-amine; With sulfuryl dichloride; triethylamine; In dichloromethane; at -78 ℃;

5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; In tetrahydrofuran; for 4h;

Reference yield:

: 481075-58-5
2-bromo-1-iodo-4-(trifluoromethyl)benzene

: 1454666-24-0
5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; 1,4-dioxane / 100 °C

1.2: 3 h / 130 °C / Microwave irradiation

2.1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

3.1: triethylamine; sulfuryl dichloride / dichloromethane / -78 °C

3.2: 4 h

With methanol; sulfuryl dichloride; potassium carbonate; triethylamine; acetyl chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1454667-10-7
tert-butyl 5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1454666-24-0
5-(2-bromo-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

2.1: triethylamine; sulfuryl dichloride / dichloromethane / -78 °C

2.2: 4 h

With methanol; sulfuryl dichloride; triethylamine; acetyl chloride; In tetrahydrofuran; dichloromethane;