[1,1'-BIPHENYL]-2-CARBOXALDEHYDE,4-METHOXY-

Base Information

• Chemical Name: [1,1'-BIPHENYL]-2-CARBOXALDEHYDE,4-METHOXY-
• CAS No.: 934691-48-2
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.248
• Mol file: 934691-48-2.mol

Synonyms:4-methoxy-[1,1'-biphenyl]-2-carbaldehyde

Chemical Property of [1,1'-BIPHENYL]-2-CARBOXALDEHYDE,4-METHOXY-

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-2-phenylbenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1,1'-BIPHENYL]-2-CARBOXALDEHYDE,4-METHOXY-

There total 7 articles about [1,1'-BIPHENYL]-2-CARBOXALDEHYDE,4-METHOXY- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-5-methoxy-benzaldehyde (7507-86-0) + phenylboronic acid (98-80-6) → 4-methoxy-[1,1'-biphenyl]-2-carbaldehyde (934691-48-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;

DOI:10.3762/bjoc.17.181

Reference yield: 91.0%

N-tert-butyl-1-(2,5-dimethoxyphenyl)methanimine + phenylmagnesium bromide (100-58-3) → 4-methoxy-[1,1'-biphenyl]-2-carbaldehyde (934691-48-2)

Guidance literature:

N-tert-butyl-1-(2,5-dimethoxyphenyl)methanimine; With chromium dichloride; In tetrahydrofuran; at 25 ℃; for 0.0833333h; Schlenk technique; Inert atmosphere;

phenylmagnesium bromide; In tetrahydrofuran; at 25 ℃; for 5h; Schlenk technique; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 25 ℃; for 3h; Reagent/catalyst; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.5b08621

Reference yield: 85.0%

1-Bromo-3-phenylpropane (637-59-2) + N-(2-(diphenylphosphino)-5-methoxybenzylidene)-2-methylpropan-2-amine + phenylmagnesium bromide (100-58-3) → 4-methoxy-[1,1'-biphenyl]-2-carbaldehyde (934691-48-2) + (3-phenylpropyl)diphenylphosphine (162616-46-8)

Guidance literature:

1-Bromo-3-phenylpropane; N-(2-(diphenylphosphino)-5-methoxybenzylidene)-2-methylpropan-2-amine; With chromium(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere; Sealed tube; Schlenk technique;

phenyl magensium bromide; In tetrahydrofuran; at 40 ℃; for 12h; Inert atmosphere; Sealed tube; Schlenk technique;

With hydrogenchloride; water monomer; In tetrahydrofuran; at 20 ℃; for 3h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.1c04325

upstream raw materials:

2-bromo-5-methoxy-benzaldehyde

phenylboronic acid

triphenylbismuthane

2,5-dimethoxybenzaldehyde

Downstream raw materials:

8-methoxy-6H-dibenzo[b,d]pyran-6-one

C₂₁H₁₉NO₃S

2-methoxy-9-[(4-methylphenyl)sulfonylamino]fluorene