1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene

Base Information

Chemical Name:1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene
CAS No.:1474060-73-5
Molecular Formula:C₂₃H₂₉NO₆
Molecular Weight:415.486
Hs Code.:

Synonyms:1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene

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Chemical Property of 1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene

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Technology Process of 1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene

There total 7 articles about 1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1-iodo-1-(3,4,5-trimethoxyphenyl)ethylene

: 1474060-74-6
3-(N-tert-butyloxycarbonylamino)-4-methoxyphenyl iodide

: 1474060-73-5
1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene

Guidance literature:: 1-iodo-1-(3,4,5-trimethoxyphenyl)ethylene; With TurboGrignard; In tetrahydrofuran; at -20 ℃; for 0.333333h; Inert atmosphere; Schlenk technique; Sealed tube;

With zinc(II) chloride; In tetrahydrofuran; at -20 - 20 ℃;

3-(N-tert-butyloxycarbonylamino)-4-methoxyphenyl iodide; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1055/s-0033-1339334

Reference yield:

: 53560-33-1
3,4,5-trimethoxyphenylacetylene

: 1474060-73-5
1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C / Inert atmosphere; Sealed tube; Schlenk technique

1.2: 1.5 h / -78 °C

2.1: TurboGrignard / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere; Schlenk technique; Sealed tube

2.2: -20 - 20 °C

2.3: 5 h / 20 °C / Inert atmosphere

With TurboGrignard; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diisobutylaluminium hydride; In tetrahydrofuran; toluene; 2.2: |Negishi Coupling / 2.3: |Negishi Coupling;
DOI:10.1055/s-0033-1339334

Reference yield:

: 77770-09-3
3-amino-4-methyloxyphenyliodide

: 1474060-73-5
1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 36 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere; Schlenk technique; Sealed tube

2.2: -20 - 20 °C

2.3: 5 h / 20 °C / Inert atmosphere

With TurboGrignard; In tetrahydrofuran; ethanol; 2.2: |Negishi Coupling / 2.3: |Negishi Coupling;
DOI:10.1055/s-0033-1339334