Technology Process of 1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene
There total 7 articles about 1-[3'-(N-tert-butyloxycarbonylamino)-4'-methoxyphenyl]-1-(3'',4'',5''-trimethoxyphenyl)ethylene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-iodo-1-(3,4,5-trimethoxyphenyl)ethylene;
With
TurboGrignard;
In
tetrahydrofuran;
at -20 ℃;
for 0.333333h;
Inert atmosphere;
Schlenk technique;
Sealed tube;
With
zinc(II) chloride;
In
tetrahydrofuran;
at -20 - 20 ℃;
3-(N-tert-butyloxycarbonylamino)-4-methoxyphenyl iodide;
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate;
In
tetrahydrofuran;
at 20 ℃;
for 5h;
Inert atmosphere;
DOI:10.1055/s-0033-1339334
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 0 - 20 °C / Inert atmosphere; Sealed tube; Schlenk technique
1.2: 1.5 h / -78 °C
2.1: TurboGrignard / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.2: -20 - 20 °C
2.3: 5 h / 20 °C / Inert atmosphere
With
TurboGrignard; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
2.2: |Negishi Coupling / 2.3: |Negishi Coupling;
DOI:10.1055/s-0033-1339334
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ethanol / 36 h / 20 °C
2.1: TurboGrignard / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.2: -20 - 20 °C
2.3: 5 h / 20 °C / Inert atmosphere
With
TurboGrignard;
In
tetrahydrofuran; ethanol;
2.2: |Negishi Coupling / 2.3: |Negishi Coupling;
DOI:10.1055/s-0033-1339334
