1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid

Base Information

Chemical Name:1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid
CAS No.:228259-35-6
Molecular Formula:C₁₇H₁₈F₃N₃O₄
Molecular Weight:385.343
Hs Code.:

Synonyms:1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid

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Chemical Property of 1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid

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Technology Process of 1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid

There total 9 articles about 1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 228259-35-6
1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid

Guidance literature:

Reference yield:

: aq. sodium bisulfite

: 228259-34-5
t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

: 228259-35-6
1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid

Guidance literature:: With potassium permanganate; sodium dihydrogenphosphate; sodium hydrogencarbonate; sodium chloride; In ethanol; acetone; tert-butyl alcohol;

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 228259-35-6
1-(2-([(t-butoxycarbonyl)amino]methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 4.76 g / aq. NH₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 100 percent / Et₃N; trichloroacetyl chloride / CH₂Cl₂ / 1.42 h / 0 - 20 °C

5: 90 percent / cobalt chloride; sodium borohydride / dimethylformamide / 23.75 h / 0 - 20 °C

6: 76 percent / Et₃N / tetrahydrofuran / 17 h / 20 °C

7: 27 percent / KMnO₄; aq. NaH₂PO₄ / 2-methyl-propan-2-ol / 1.25 h / 60 °C

With ammonium hydroxide; sodium tetrahydroborate; potassium permanganate; sodium dihydrogenphosphate; cobalt chloride; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetyl chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm030212h