N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide

Base Information

Chemical Name:N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide
CAS No.:1380228-04-5
Molecular Formula:C₁₉H₁₇F₂N₇O₂S
Molecular Weight:445.452
Hs Code.:

Synonyms:N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide

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Chemical Property of N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide

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Technology Process of N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide

There total 29 articles about N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1380228-80-7
N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide

: 1380228-04-5
N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide

Guidance literature:: With trifluoroacetic acid; In methanol; at 20 ℃;

Reference yield:

: 385-00-2
2,6-difluorobenzoic acid

: 1380228-04-5
N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 2 h / Reflux

1.2: 2 h / 20 °C

2.1: sulfuric acid / 2 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4.1: pyridine / 1,2-dichloro-ethane / 5 h / 100 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

6.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C

6.2: 80 °C

7.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 60 °C

8.1: trifluoroacetic acid / methanol / 20 °C

With pyridine; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

Reference yield:

: 1103234-57-6
N-(3-amino-2,4-difluorophenyl)propane-1-sulfonamide

: 1380228-04-5
N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 60 °C

2: trifluoroacetic acid / methanol / 20 °C

With sodium hexamethyldisilazane; trifluoroacetic acid; In tetrahydrofuran; methanol;