Technology Process of N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide
There total 29 articles about N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
methanol;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: thionyl chloride / 2 h / Reflux
1.2: 2 h / 20 °C
2.1: sulfuric acid / 2 h / 20 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
4.1: pyridine / 1,2-dichloro-ethane / 5 h / 100 °C
5.1: lithium hydroxide; water / tetrahydrofuran / 20 °C
6.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C
6.2: 80 °C
7.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 60 °C
8.1: trifluoroacetic acid / methanol / 20 °C
With
pyridine; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 60 °C
2: trifluoroacetic acid / methanol / 20 °C
With
sodium hexamethyldisilazane; trifluoroacetic acid;
In
tetrahydrofuran; methanol;
