1-phenyl-1-(4-methylphenyl)methyl methyl ether

Base Information

• Chemical Name: 1-phenyl-1-(4-methylphenyl)methyl methyl ether
• CAS No.: 7364-22-9
• Molecular Formula: C₁₅H₁₆O
• Molecular Weight: 212.291
• Mol file: 7364-22-9.mol

Synonyms:1-phenyl-1-(4-methylphenyl)methyl methyl ether

Chemical Property of 1-phenyl-1-(4-methylphenyl)methyl methyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-1-(4-methylphenyl)methyl methyl ether

There total 17 articles about 1-phenyl-1-(4-methylphenyl)methyl methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 4-methylphenyl(phenyl)methanol (1517-63-1) → 1-phenyl-1-(4-methylphenyl)methyl methyl ether (7364-22-9)

Guidance literature:

With sulfuric acid; for 2h; Reflux;

DOI:10.1039/c5ob01637a

Reference yield: 86.0%

iodobenzene (591-50-4) + 4-methylbenzaldehyde dimethylacetal (3395-83-3) → 1-phenyl-1-(4-methylphenyl)methyl methyl ether (7364-22-9)

Guidance literature:

With chloro-trimethyl-silane; [nickel(II)dichloride(dimethoxyethane)]; N,N-dimethyl acetamide; 2,6-bis(pyrazole)pyridine; zinc; at 23 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1002/anie.201503936

Reference yield: 85.0%

benzaldehyde dimethyl acetal (1125-88-8) + p-tolyllithium (2417-95-0) → 1-phenyl-1-(4-methylphenyl)methyl methyl ether (7364-22-9)

Guidance literature:

With boron trifluoride diethyl etherate; (-)-sparteine; In diethyl ether; at -78 ℃;

DOI:10.1002/1099-0690(200111)2001:21<4137::AID-EJOC4137>3.0.CO;2-4

upstream raw materials:

methanol

4-methylphenyl(phenyl)methanol

(+/-)-4-methylbenzhydryl hemiphthalate

(4-methylphenyl)phenylmethylene

Downstream raw materials:

1-[3-(4-methylphenyl)-3-phenylpropyl]-N,N-dimethylamine

Refernces

• 1、 Arendt, Kevin M.,Doyle, Abigail G.. "Dialkyl Ether Formation by Nickel-Catalyzed Cross-Coupling of Acetals and Aryl Iodides". . p. 9876 - 9880. Retrieved 2015/08/19.
• 2、 Mueller, Paul,Nury, Patrice,Bernardinelli, Gerald. "Asymmetric nucleophilic substitution of acetals". . p. 4137 - 4147. Retrieved 2007/10/03.