(2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid

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Chemical Name:(2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid
CAS No.:719307-48-9
Molecular Formula:C₂₈H₃₈N₂O₇
Molecular Weight:514.619
Hs Code.:

Synonyms:(2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid

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Chemical Property of (2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid

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Technology Process of (2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid

There total 10 articles about (2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: (2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid tert-butyl ester

: 719307-48-9
(2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid

Guidance literature:: With trifluoroacetic acid; In toluene; at 20 ℃; for 18h; Azeotropic distillation;

Reference yield:

: 4668-43-3
(S)-3-(benzyloxycarbonylamino)-4-ethoxy-4-oxobutanoic acid

: 719307-48-9
(2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C

3: trichlorophosphate / toluene / 1.5 h / 100 °C

4: hydrogen bromide; acetic acid / 1 h / 20 °C

5: hydrogenchloride / diethyl ether

6: toluene / 18 h / 70 °C / Azeotropic distillation

7: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

8: trifluoroacetic acid / toluene / 18 h / 20 °C / Azeotropic distillation

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; hydrogen bromide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; trichlorophosphate; N,N-dimethyl-formamide; In diethyl ether; dichloromethane; toluene;

Reference yield:

: (S)-2-Benzyloxycarbonylamino-succinic acid 1-ethyl ester; compound with dicyclohexyl-amine

: 719307-48-9
(2S)-2-{1-[(1S)-1-isobutoxycarbonyl-2-(5-phenyl-oxazol-2-yl)-ethylcarbamoyl]-cyclopentylmethyl}4-methoxy-butyric acid

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid; water / diethyl ether / 18 h / Heating / reflux

2: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C

4: trichlorophosphate / toluene / 1.5 h / 100 °C

5: hydrogen bromide; acetic acid / 1 h / 20 °C

6: hydrogenchloride / diethyl ether

7: toluene / 18 h / 70 °C / Azeotropic distillation

8: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

9: trifluoroacetic acid / toluene / 18 h / 20 °C / Azeotropic distillation

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; sulfuric acid; water; hydrogen bromide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; trichlorophosphate; N,N-dimethyl-formamide; In diethyl ether; dichloromethane; toluene;