Technology Process of methyl 5-cyano-2-(difluoromethyl)benzoate
There total 3 articles about methyl 5-cyano-2-(difluoromethyl)benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine;
In
N,N-dimethyl-formamide;
at 20 - 80 ℃;
for 72h;
under 1035.1 Torr;
Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01249
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / tetrachloromethane / 48 h / 95 °C
2: silver tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere
3: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / 72 h / 20 - 80 °C / 1035.1 Torr / Inert atmosphere
With
N-Bromosuccinimide; silver tetrafluoroborate; 1,3-bis-(diphenylphosphino)propane; triethylamine;
palladium diacetate;
In
tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: silver tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere
2: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / 72 h / 20 - 80 °C / 1035.1 Torr / Inert atmosphere
With
silver tetrafluoroborate; 1,3-bis-(diphenylphosphino)propane; triethylamine;
palladium diacetate;
In
dichloromethane; N,N-dimethyl-formamide;
