1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone

Base Information

Chemical Name:1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone
CAS No.:1431323-75-9
Molecular Formula:C₁₃H₉Cl₃N₂OS
Molecular Weight:347.652
Hs Code.:

Synonyms:1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone

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Chemical Property of 1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone

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Technology Process of 1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone

There total 4 articles about 1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 307531-80-2
(2,6-dichlorobenzyl)zinc(II) chloride

: 55084-66-7
4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

: 1431323-75-9
1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone

Guidance literature:: (2,6-dichlorobenzyl)zinc(II) chloride; With copper(l) cyanide; lithium chloride; In tetrahydrofuran; at -25 ℃; for 0.25h;

4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride; In tetrahydrofuran; at -25 - 2 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.bmcl.2019.04.017

Reference yield:

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 1431323-75-9
1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 60 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 90 °C

3.1: copper(l) cyanide; lithium chloride / tetrahydrofuran / 0.25 h / -25 °C

3.2: 1.5 h / -25 - 2 °C / Inert atmosphere

With thionyl chloride; water; copper(l) cyanide; N,N-dimethyl-formamide; lithium chloride; sodium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2019.04.017

Reference yield:

: 74840-34-9
4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

: 1431323-75-9
1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 90 °C

2.1: copper(l) cyanide; lithium chloride / tetrahydrofuran / 0.25 h / -25 °C

2.2: 1.5 h / -25 - 2 °C / Inert atmosphere

With thionyl chloride; copper(l) cyanide; N,N-dimethyl-formamide; lithium chloride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2019.04.017