FMOC-METRP-OH

Base Information

• Chemical Name: FMOC-METRP-OH
• CAS No.: 112913-63-0
• Molecular Formula: C27H24 N2 O4
• Molecular Weight: 440.49
• Mol file: 112913-63-0.mol

Synonyms:FMOC-TRP(ME)-OH;FMOC-N-METHYL-L-TRYPTOPHAN;FMOC-N-ME-TRP-OH;FMOC-N-ME-TRYPTOPHAN;FMOC-N-ALPHA-METHYL-L-TRYPTOPHAN;FMOC-METRP-OH;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-TRYPTOPHAN;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-L-TRYPTOPHAN

Chemical Property of FMOC-METRP-OH

Chemical Property:

• Boiling Point: 683.3±55.0 °C(Predicted)
• PKA: 3.90±0.10(Predicted)
• PSA: 82.63000
• Density: 1.331±0.06 g/cm3(Predicted)
• LogP: 5.04450
• Storage Temp.: Store at RT.

Purity/Quality:

98%min ^*data from raw suppliers

Fmoc-Nalpha-methyl-L-tryptophan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-METRP-OH

There total 1 articles about FMOC-METRP-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) + L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) → (S)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-3-(1H-indol-3-yl)-propionic acid (112913-63-0)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4039(97)01774-7

Reference yield:

C44H50ClN4O6Pol + (S)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-3-(1H-indol-3-yl)-propionic acid (112913-63-0) → C71H72ClN6O9Pol

Guidance literature:

With benzotriazol-1-ol; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere; solid phase reaction;

DOI:10.1021/ol801064d

Reference yield:

C44H50ClN4O6Pol + (S)-2-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-3-(1H-indol-3-yl)-propionic acid (112913-63-0) → C71H72ClN6O9Pol

Guidance literature:

With benzotriazol-1-ol; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere; solid phase reaction;

DOI:10.1021/ol801064d

upstream raw materials:

methanol

(fluorenylmethoxy)carbonyl chloride

L-Tryptophan

Downstream raw materials:

C₈₁H₁₁₆N₂₀O₂₄

Refernces