(3E)-7-{(5S)-2-hydroxy-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyltetrahydro-2H-pyran-2-yl}hept-3-en-2-yl acetate

Base Information

Chemical Name:(3E)-7-{(5S)-2-hydroxy-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyltetrahydro-2H-pyran-2-yl}hept-3-en-2-yl acetate
CAS No.:1340479-64-2
Molecular Formula:C₃₉H₅₂O₅Si
Molecular Weight:628.924
Hs Code.:

Synonyms:(3E)-7-{(5S)-2-hydroxy-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyltetrahydro-2H-pyran-2-yl}hept-3-en-2-yl acetate

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Chemical Property of (3E)-7-{(5S)-2-hydroxy-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyltetrahydro-2H-pyran-2-yl}hept-3-en-2-yl acetate

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Technology Process of (3E)-7-{(5S)-2-hydroxy-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyltetrahydro-2H-pyran-2-yl}hept-3-en-2-yl acetate

There total 11 articles about (3E)-7-{(5S)-2-hydroxy-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyltetrahydro-2H-pyran-2-yl}hept-3-en-2-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7217-71-2
1-phenyl-2-propenyl acetate

: 1340479-63-1
(5S,6R)-6-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyl-2-(pent-4-en-1-yl)tetrahydro-2H-pyran-2-ol

: 1340479-72-2
(2R,3S)-2-{3-[(tert-butyldiphenyl)oxy]propyl}-3-methyl-6-(pent-4-en-1-yl)-3,4-dihydro-2H-pyran

: 1340479-73-3
C₃₉H₅₀O₄Si

: 1340479-64-2
(3E)-7-{(5S)-2-hydroxy-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyltetrahydro-2H-pyran-2-yl}hept-3-en-2-yl acetate

: 1340479-74-4
C₃₉H₅₂O₅Si

Guidance literature:: 1-phenyl-2-propenyl acetate; (5S,6R)-6-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyl-2-(pent-4-en-1-yl)tetrahydro-2H-pyran-2-ol; With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 80 ℃; Inert atmosphere; Microwave irradiation;

With camphor-10-sulfonic acid; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ol202483u

Reference yield:

: 1119-51-3
bromopentene

: 1340479-73-3
C₃₉H₅₀O₄Si

: 1340479-64-2
(3E)-7-{(5S)-2-hydroxy-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyltetrahydro-2H-pyran-2-yl}hept-3-en-2-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / diethyl ether / 4.25 h / Inert atmosphere; Reflux

2.1: diethyl ether; cyclohexane / 16 h / -20 °C / Inert atmosphere

3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 80 °C / Inert atmosphere; Microwave irradiation

3.2: 2 h / 20 °C / Inert atmosphere; Microwave irradiation

With Hoveyda-Grubbs catalyst second generation; iodine; magnesium; In diethyl ether; dichloromethane; cyclohexane;
DOI:10.1021/ol202483u

Reference yield:

: 34164-50-6
4-penten-1-ylmagnesium bromide

: 1340479-73-3
C₃₉H₅₀O₄Si

: 1340479-64-2
(3E)-7-{(5S)-2-hydroxy-{3-[(tert-butyldiphenyl)oxy]propyl}-5-methyltetrahydro-2H-pyran-2-yl}hept-3-en-2-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether; cyclohexane / 16 h / -20 °C / Inert atmosphere

2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 80 °C / Inert atmosphere; Microwave irradiation

2.2: 2 h / 20 °C / Inert atmosphere; Microwave irradiation

With Hoveyda-Grubbs catalyst second generation; In diethyl ether; dichloromethane; cyclohexane;
DOI:10.1021/ol202483u