N-(2-methylbenzoyl)saccharin

Base Information

• Chemical Name: N-(2-methylbenzoyl)saccharin
• CAS No.: 52707-92-3
• Molecular Formula: C₁₅H₁₁NO₄S
• Molecular Weight: 301.323
• Mol file: 52707-92-3.mol

Synonyms:N-(2-methylbenzoyl)saccharin

Chemical Property of N-(2-methylbenzoyl)saccharin

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-methylbenzoyl)saccharin

There total 3 articles about N-(2-methylbenzoyl)saccharin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ortho-toluoyl chloride (933-88-0) + saccharin (81-07-2) → N-(2-methylbenzoyl)saccharin (52707-92-3)

Guidance literature:

With triethylamine; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.6b02294

Reference yield: 65.0%

ortho-methylbenzoic acid (118-90-1) + saccharin (81-07-2) → N-(2-methylbenzoyl)saccharin (52707-92-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In chloroform; at 80 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1055/s-0039-1690178

Reference yield:

→ N-(2-methylbenzoyl)saccharin (52707-92-3)

Guidance literature:

/BRN= 213625/;

DOI:10.1039/jr9570000490

upstream raw materials:

ortho-toluoyl chloride

saccharin

ortho-methylbenzoic acid

Downstream raw materials:

butyl (2E)-3-(2-methylphenyl)acrylate

2-methylphenyl aldehyde

o-toluic acid n-butyl ester

2-Methylbenzophenone